We report two cases of chronic aortic dissection whose prominent featu
res were characterized by systemic symptoms (prolonged low grade fever
, fatigue, weight loss) and biological acute phase response. In the fi
rst patient, a surgical repair of the descending thoracic aorta aneury
sm was performed, allowing the disappearance of general manifestations
, whereas spontaneous resolution occurred in the second case. Although
aortic dissection is usually an acute and highly symptomatic event, t
he disorder can present - albeit rarely - as systemic illness and feve
r of unknown origin.