A 33-day-old male infant who developed central diabetes insipitus as a
complication of congenital toxoplasmosis is presented. He had polyuri
a and hypernatremia on admission and responded to Intranasal desmopres
sin acetate with the normalization of abovementioned findings. Compute
d tomographic (CT) scan of the brain showed obstructive hydrocephaly w
ith periventricular and right basal ganglion calcification. CT scan of
the pituitary gland, thyroid function tests, and serum cortisol level
s were all normal. This is the first report of isolated diabetes insip
itus with congenital toxoplasmosis in literature and central diabetes
insipitus should be remembered if polyuria and hypernatremia develops
in a patient with congenital toxoplasmosis.