MRI-NEUROPATHOLOGICAL CORRELATIONS IN TYPE-1 LISSENCEPHALY

Although imperfect, MRI is the best way of distinguishing type 1 lisse ncephaly from other, less classical lissencephalic malformations. We r eported a case in which correlation of MRI and neuropathology was poss ible. Besides the classical radiological features of lissencephaly, i. e., agyria and excessive thickness of the cortex, an additional sign w as observed: a thin cortical band, which gave high signal on T2-weight ed images, represented a paucicellular and partially myelinated band, 1500 mu m thick, lying under the true superficial cortex. This MRI fea ture could be characteristic of the particular cortical lamination obs erved in true type 1 lissencephaly.