ALPHA-MANNOSYL CLUSTERS SCAFFOLDED ON AZAMACROCYCLES - SYNTHESIS AND INHIBITORY PROPERTIES IN THE ADHESION OF TYPE-1 FIMBRIATED ESCHERICHIA-COLI TO GUINEA-PIG ERYTHROCYTES

Authors
KONIG B FRICKE T WASSMANN A KRALLMANNWENZEL U LINDHORST TK
Citation
B. Konig et al., ALPHA-MANNOSYL CLUSTERS SCAFFOLDED ON AZAMACROCYCLES - SYNTHESIS AND INHIBITORY PROPERTIES IN THE ADHESION OF TYPE-1 FIMBRIATED ESCHERICHIA-COLI TO GUINEA-PIG ERYTHROCYTES, Tetrahedron letters, 39(16), 1998, pp. 2307-2310
Citations number
28
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
16
Year of publication
1998
Pages
2307 - 2310
Database
ISI
SICI code
0040-4039(1998)39:16<2307:ACSOA->2.0.ZU;2-L
Abstract
The reaction of azamacrocycles, such as la and Ib, with acetyl-protect ed alpha-D-mannosyl isothiocyanate yields thiourea-bridged tetravalent glycoclusters 3 as novel neoglycoconjugates in one step The deprotect ed compounds 4 showed significant inhibition of the adhesion of type 1 fimbriated Escherichia coli to Guinea pig erythrocytes. (C) 1998 Else vier Science Ltd. All rights reserved.