TOTAL SYNTHESIS OF CALLYSTATIN-A, A POTENT CYTOTOXIC POLYKETIDE FROM THE MARINE SPONGE, CALLYSPONGIA-TRUNCATA

Authors
MURAKAMI N WANG WQ AOKI M TSUTSUI Y SUGIMOTO M KOBAYASHI M
Citation
N. Murakami et al., TOTAL SYNTHESIS OF CALLYSTATIN-A, A POTENT CYTOTOXIC POLYKETIDE FROM THE MARINE SPONGE, CALLYSPONGIA-TRUNCATA, Tetrahedron letters, 39(16), 1998, pp. 2349-2352
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
16
Year of publication
1998
Pages
2349 - 2352
Database
ISI
SICI code
0040-4039(1998)39:16<2349:TSOCAP>2.0.ZU;2-D
Abstract
A first total synthesis of callystatin A (1), a potent cytotoxic polyk etide from the marine sponge Callyspongia truncata, has been achieved by use of an E-selective Wittig olefination and asymmetric Evans aldol condensation as the key reactions. Thus, the absolute stereostructure of 1 previously established by us was confirmed. (C) 1998 Elsevier Sc ience Ltd. All rights reserved.