Purpose: A retrospective review of a large group of transrectal ultras
ound guided biopsies was performed to determine the symptomatic urinar
y tract infection rate associated with a consistent and defined antibi
otic prophylaxis regimen. Materials and Methods: A total of 4,439 biop
sies was performed using an 18 gauge needle with ultrasound guidance.
Patients were treated with 500 mg. ciprofloxacin twice daily for 8 dos
es beginning the day before biopsy. Results: Of 5 symptomatic urinary
tract infections noted 3 were complicated. Conclusions: These data dem
onstrate the low infection rate associated with this prophylaxis regim
en.