INDUCTION OF HEME OXYGENASE-1 IN TOXIC RENAL INJURY - MERCURIC CHLORIDE-INDUCED ACUTE-RENAL-FAILURE IN RAT

Authors
HORIKAWA S ITO K IKEDA S SHIBATA T ISHIZUKA S YANO T HAGIWARA K OZASA H KATSUYAMA I
Citation
S. Horikawa et al., INDUCTION OF HEME OXYGENASE-1 IN TOXIC RENAL INJURY - MERCURIC CHLORIDE-INDUCED ACUTE-RENAL-FAILURE IN RAT, Toxicology letters, 94(1), 1998, pp. 57-64
Citations number
25
Categorie Soggetti
Toxicology
Journal title
Toxicology letters → ACNP
ISSN journal
03784274
Volume
94
Issue
1
Year of publication
1998
Pages
57 - 64
Database
ISI
SICI code
0378-4274(1998)94:1<57:IOHOIT>2.0.ZU;2-W
Abstract
It is known that mercuric chloride (HgCl2) is a nephrotoxicant. When H gCl2 (1 mg/kg body weight) was intraperitoneally injected into rats, a cute renal failure was induced. Histological changes in the kidneys we re exclusively observed in the proximal tubules and the severe necrosi s was found as early as 24 h after HgCl2 injection. The heme oxygenase -1 (HO-1) mRNA was strongly and promptly induced at about 2.5 h, the e arliest time examined and abruptly decreased after the injection. Wher eas the time course of HO-1 protein level was delayed as compared with that of HO-1 mRNA level. The levels of HO-I mRNA and protein similarl y increased with dose-dependent manner. The localization of HO-1 prote in was restricted to the tubule cells. These findings suggest the pote ntial involvement of HO-1 induction in the response to HgCl2-induced a cute renal injury. (C) 1998 Elsevier Science Ireland Ltd. All rights r eserved.