INCREASED STRIATAL DOPAMINE PRODUCTION FROM L-DOPA FOLLOWING SELECTIVE-INHIBITION OF MONOAMINE-OXIDASE-B BY R(-N-PROPARGYL-1-AMINOINDAN (RASAGILINE) IN THE MONKEY())

Striatal extracellular fluid concentrations of dopamine and metabolite s in response to direct striatal administration of two L-DOPA boluses administered sequentially were determined in three rhesus monkeys duri ng halothane anesthesia. Whereas in an initial microdialysis run, gene ration of dopamine was less following the second L-DOPA bolus than the first, in a subsequent run, in which the selective MAO-B inhibitor R( +)-N-propargyl-1-aminoindan (rasagiline) was administered systemically (0.2 mg/kg s.c.) between the two L-DOPA boluses, generation of dopami ne was greater following the second bolus.