ULTRASOUND-GUIDED FINE-NEEDLE ASPIRATION CYTOLOGY DIAGNOSIS OF GALLBLADDER LESIONS - A STUDY OF 82 CASES

Carcinoma of the gallbladder (GB) is among the five most common forms of cancers and tops the list of gastrointestinal malignancies in femal es of the Delhi region. Lack of specific signs and symptoms prevents e arly detection of GB carcinoma. However, in recent years ultrasonograp hically (US)-guided fine-needle aspiration (FNA) cytology has been fou nd to be a reliable procedure for its diagnosis. The present study was carried out during a period of 5 yr (1986-1990) in 64 female and 18 m ale patients to find out the diagnostic utility of US-guided FNA cytol ogy in gallbladder lesions. Ultrasonography in these 82 cases revealed a mass in the gallbladder/GB area in 74 (90.2%), a mass in the GB/pan creas in 1 (1.2%), gallstones in 32 (39.0%), and miscellaneous gallbla dder lesions in 4 (4.9%). The other findings included space-occupying lesions in liver in 18 (22.0%), portal lymphadenopathy in 12 (14.6%), and infiltration in other organs in 7 (8.5%). The initial cytodiagnosi s was malignancy in 48 cases, inflammatory in 12, and inadequate in 22 . Following review of the smears by one of the investigators (D.K.D.), the number of malignant cases remained 48 (58.5%). There were 10 (12. 2%) inflammatory and 24 (29.3%) inadequate cases. Adenocarcinoma was t he most common malignancy (83.3%), followed by squamous-cell and adeno squamous carcinoma (12.5%) and small round cell tumors (4.2%). The 10 inflammatory lesions showed slight (+) to excessive (+++) neutrophilic infiltration and included one case each of xanthogranulomatous cholec ystitis and a necrotizing granulomatous lesion likely to be of tubercu lous etiology. (C) 1998 Wiley-Liss, Inc.