SYNTHESIS AND BIOLOGICAL-ACTIVITY OF SOME 4-AMINO-3-CINNOLINE CARBOXYLIC-ACID DERIVATIVES - PART-4 - -DIOXO-1,2,3,4-TETRAHYDROPYRIMIDO[5,4-C]CINNOLINES

Authors
STANCZAK A LEWGOWD W PAKULSKA W
Citation
A. Stanczak et al., SYNTHESIS AND BIOLOGICAL-ACTIVITY OF SOME 4-AMINO-3-CINNOLINE CARBOXYLIC-ACID DERIVATIVES - PART-4 - -DIOXO-1,2,3,4-TETRAHYDROPYRIMIDO[5,4-C]CINNOLINES, Die Pharmazie, 53(3), 1998, pp. 156-161
Citations number
14
Categorie Soggetti
Pharmacology & Pharmacy","Chemistry Medicinal
Journal title
Die Pharmazie → ACNP
ISSN journal
00317144
Volume
53
Issue
3
Year of publication
1998
Pages
156 - 161
Database
ISI
SICI code
0031-7144(1998)53:3<156:SABOS4>2.0.ZU;2-W
Abstract
A series of new -dioxo-1,2,3,4-tetrahydropyrimido[5,4-c]cinnolines and their 3-substituted derivatives were prepared. These compounds were o btained by cyclocondensation of the appropriate substituted 4-amino-3- cinnolinecarboxylic acid with urea or 4-amino-3-cinnolinecarboxamides with N,N-1-carbonyldiimidazole (DCl), oxalyl chloride or diethyl carbo nate. Most of these compounds showed a high sedative action in low dos es.