POTENTIOMETRIC DETERMINATION OF FAMOTIDINE IN PHARMACEUTICAL DOSAGE FORMS

Authors
PETKOVIC J MINIC D KORICANAC Z JOVANOVIC T
Citation
J. Petkovic et al., POTENTIOMETRIC DETERMINATION OF FAMOTIDINE IN PHARMACEUTICAL DOSAGE FORMS, Die Pharmazie, 53(3), 1998, pp. 163-164
Citations number
8
Categorie Soggetti
Pharmacology & Pharmacy","Chemistry Medicinal
Journal title
Die Pharmazie → ACNP
ISSN journal
00317144
Volume
53
Issue
3
Year of publication
1998
Pages
163 - 164
Database
ISI
SICI code
0031-7144(1998)53:3<163:PDOFIP>2.0.ZU;2-O
Abstract
A simple and rapid method for the determination of famotidine is descr ibed. Famotidine is titrated with a solution of palladium(II)-chloride in Britton-Robinson buffer (pH = 3.60) using a silver indicator elect rode. A stable yellow complex is formed. A significant step of the pot ential appears when the stoichiometric ratio of palladium(II) to famot idine is 1:1. The method is suitable for the determination of micro qu antities (2.5-0.8 mg) of famotidine alone or in pharmaceutical dosage forms with a relative standard deviation of 0.7-2.3%.