ANTIMICROBIAL ACTIVITY OF ORGANIC THIOSULFATES (BUNTE SALTS)

A number of organic thiosulfates (Bunte salts) were prepared from appr opriate primary bromides or iodides. In the case of substrates with lo ng aliphatic chains, an addition of benzyltrimethylammonium chloride a s phase transfer catalyst was very successful. The Bunte salts obtaine d were tested for antibacterial and fungicidal activity by means of th e agar disc-diffusion method and by assignation of the minimum inhibit ory concentrations (MIC). It was found that the microorganisms Proteus vulgaris, Candida albicans and Staphylococcus aureus showed the highe st sensitivity. Biological activity of the compounds studied was depen dent on the length of the aliphatic chain. Among the investigated comp ounds, aliphatic thiosulfates with 10-13 carbon atom chain were the mo st potent.