MONITORING OF LIQUID-PHASE PEPTIDE-SYNTHESIS ON SOLUBLE POLYMER SUPPORTS VIA MATRIX-ASSISTED-LASER-DESORPTION IONIZATION TIME-OF-FLIGHT MASS-SPECTROMETRY/

Authors
THURMER R MEISENBACH M ECHNER H WEILER A ALQAWASMEH RA VOELTER W KORFF U SCHMITTSODY W
Citation
R. Thurmer et al., MONITORING OF LIQUID-PHASE PEPTIDE-SYNTHESIS ON SOLUBLE POLYMER SUPPORTS VIA MATRIX-ASSISTED-LASER-DESORPTION IONIZATION TIME-OF-FLIGHT MASS-SPECTROMETRY/, Rapid communications in mass spectrometry, 12(7), 1998, pp. 398-402
Citations number
25
Categorie Soggetti
Spectroscopy,"Chemistry Analytical
Journal title
Rapid communications in mass spectrometry → ACNP
ISSN journal
09514198
Volume
12
Issue
7
Year of publication
1998
Pages
398 - 402
Database
ISI
SICI code
0951-4198(1998)12:7<398:MOLPOS>2.0.ZU;2-H
Abstract
Taking the enkephalin synthesis on soluble polyethylene glycol support as a test case, this communication demonstrates the usefulness of mat rix-assisted laser desorption/ionization time-of-flight mass spectrome try to monitor each step of coupling as well as removal of the N-termi nal protecting group of the polymer-bound growing peptide chain, With minute amounts of sample the high mass accuracy permits detection of s ide reactions as well as incomplete reaction products. (C) 1998 John W iley & Sons, Ltd.