GLYCOSIDOPYRROLES - PART 1 - ACYCLIC DERIVATIVES - 1-(2-HYDROXYETHOXY)METHYLPYRROLES AS POTENTIAL ANTIVIRAL AGENTS

Authors
ALMERICO AM DIANA P BARRAJA P DATTOLO G MINGOIA F LOI AG SCINTU F MILIA C PUDDU I LACOLLA P
Citation
Am. Almerico et al., GLYCOSIDOPYRROLES - PART 1 - ACYCLIC DERIVATIVES - 1-(2-HYDROXYETHOXY)METHYLPYRROLES AS POTENTIAL ANTIVIRAL AGENTS, Il Farmaco, 53(1), 1998, pp. 33-40
Citations number
13
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Il Farmaco → ACNP
ISSN journal
0014827X
Volume
53
Issue
1
Year of publication
1998
Pages
33 - 40
Database
ISI
SICI code
0014-827X(1998)53:1<33:G-P1-A>2.0.ZU;2-C
Abstract
Acyclic glycosidopyrroles of type 1, synthesized in good overall yield s, were evaluated for anti-viral activity. Compound 10i was found to i nhibit the HIV-1 replication at concentrations that were very close to those cytotoxic for MT-4 cells. Compounds 10a,f,i inhibited both stra ins HSV-1 and HSV-2 at concentrations slightly below those cytotoxic f or Vero cells. However for this series of glycosidopyrroles some relat ionship between calculated log P values and the observed cytotoxicity was found. (C) 1998 Elsevier Science S.A.