DIASTEREOMERIC SEPARATION OF 1,5-BENZODIAZEPINES DUE TO THE PRESENCE OF A CHIRAL CENTER ON THE N-5 ALKYLIC CHAIN

Authors
ARALDI GL DONATI D TRANQUILLINI ME URSINI A
Citation
Gl. Araldi et al., DIASTEREOMERIC SEPARATION OF 1,5-BENZODIAZEPINES DUE TO THE PRESENCE OF A CHIRAL CENTER ON THE N-5 ALKYLIC CHAIN, Il Farmaco, 53(1), 1998, pp. 49-54
Citations number
22
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Il Farmaco → ACNP
ISSN journal
0014827X
Volume
53
Issue
1
Year of publication
1998
Pages
49 - 54
Database
ISI
SICI code
0014-827X(1998)53:1<49:DSO1DT>2.0.ZU;2-Y
Abstract
The presence of a chain bearing a stereogenic centre at the N-5 positi on of methyl)-3-arylureido-2,4-dioxo-1,5-benzodiazepines induces optic al resolution. The synthesis of these compounds and their potency as p otential CCK-B receptor antagonists is discussed briefly here. (C) 199 8 Elsevier Science S.A.