A series of ergoline-amides was synthesised in the discovery of new do
paminomimetic agents. Several compounds exhibited in vivo high prolact
in lowering activity (indirectly measured by the nidation test) in rat
s. For the most active, the potential anti-Parkinson activity was eval
uated by observation of the contralateral turning behaviour in 6-OH-DA
lesioned rats. The acute toxicity by oral route in mice was also stud
ied. (C) 1998 Elsevier Science S.A.