ANTINOCICEPTIVE AND ANTIINFLAMMATORY ACTIVITY OF SOME (2-BENZOXAZOLONE-3-YL AND 2-BENZOTHIAZOLONE-3-YL)ACETIC ACID-DERIVATIVES

Sixteen (2-benzothiazolone-3-yl and 2-benzoxazolone-3-yl)acetic acid d erivatives 5 have been tested for anti-nociceptive and antiinflammator y activity in this study. 4-[2-(6-Benzoyl-2-benzoxazolone-3-yl)acetyl] morpholine [6-(2-chloro-benzoyl)-2-benzoxazolone-3-yl]acetyl} -morpho line (5d), -(5-chloro-2-benzoxazolone-3-yl)acetyl]pyrrolidine (5f), me thyl (6-methyl-2-benzoxazolone-3-yl)acetate (5k) and N,N-diethyl-2-(2- benzothiazolone-3-yl)acetamide (5m) have shown more potent anti-nocice ptive activity than others. Among these compounds, 5c, 5d and 5m have exhibited good anti-inflammatory activity, with 5f, and to a lesser ex tent, the other molecules displaying some toxic potential. (C) 1998 El sevier Science S.A.