ANTIOXIDANT ACTIVITY OF SOME ASCORBIC AND CINNAMIC-ACIDS DERIVATIVES

Authors
POINT D COUDERT P LEAL F RUBAT C SAUTOUMIRANDA V CHOPINEAU J COUQUELET J
Citation
D. Point et al., ANTIOXIDANT ACTIVITY OF SOME ASCORBIC AND CINNAMIC-ACIDS DERIVATIVES, Il Farmaco, 53(1), 1998, pp. 85-88
Citations number
10
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Il Farmaco → ACNP
ISSN journal
0014827X
Volume
53
Issue
1
Year of publication
1998
Pages
85 - 88
Database
ISI
SICI code
0014-827X(1998)53:1<85:AAOSAA>2.0.ZU;2-P
Abstract
Some 4-benzoyl 3-hydroxy furan-2 (5H) ones (3a-d) and 2-amino 3-hydrox ymethyl 4-aryl 4-oxo 2-butenoic acids (4a-h) have been synthesized. Co mpound 3c with an isobutyl substituent in the 5-position of the furan ring was the most effective (IC50 = 8.69 X 10(-4) M) in scavenging the superoxide anion. In vivo, 3c was also protective against reperfusion injury. (C) 1998 Elsevier Science S.A.