REFINED ENANTIOSELECTIVE METHYLATION CATALYSTS - IMPROVED ROUTES TO BIFUNCTIONAL C5 SYNTHONS

Authors
JONES GB GUZEL M CHAPMAN BJ
Citation
Gb. Jones et al., REFINED ENANTIOSELECTIVE METHYLATION CATALYSTS - IMPROVED ROUTES TO BIFUNCTIONAL C5 SYNTHONS, Tetrahedron : asymmetry, 9(6), 1998, pp. 901-905
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
9
Issue
6
Year of publication
1998
Pages
901 - 905
Database
ISI
SICI code
0957-4166(1998)9:6<901:REMC-I>2.0.ZU;2-C
Abstract
Catalytic enantioselective routes to bifunctional C5 synthons, includi ng those of the macrolide (S)-(-)-zearalenone have been achieved. Ster eochemistry was introduced using a mixed ligand arene chromium tricarb onyl catalyst to mediate the enantioselective addition of dimethyl zin c to a functionalized aldehyde. Comparison with alternate reduction st rategies is presented. (C) 1998 Elsevier Science Ltd. All rights reser ved.