STERIC HINDRANCE VERSUS ASYMMETRIC INDUCTION - NEW PN-LIGANDS FOR CARBON-CARBON COUPLING REACTIONS

Authors
BOURGHIDA M WIDHALM M
Citation
M. Bourghida et M. Widhalm, STERIC HINDRANCE VERSUS ASYMMETRIC INDUCTION - NEW PN-LIGANDS FOR CARBON-CARBON COUPLING REACTIONS, Tetrahedron : asymmetry, 9(6), 1998, pp. 1073-1083
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
9
Issue
6
Year of publication
1998
Pages
1073 - 1083
Database
ISI
SICI code
0957-4166(1998)9:6<1073:SHVAI->2.0.ZU;2-G
Abstract
Two new aminophosphine ligands 4 and 5 with increased steric interacti on in proximity to the N-coordination site have been prepared. Their a symmetric induction in five model reactions was tested and compared to results obtained with the parent ligand 2. This resulted in improved enantioselectivity in only one case, from 5 to 68% e.e., while in all the other cases the more crowded ligands exhibited significantly lower reactivity accompanied by decreased enantioselectivity. (C) 1998 Else vier Science Ltd. All rights reserved.