MULTIPLE AGMINATE SPITZ NEVI

Authors
HULSHOF MM VANHAERINGEN A GRUIS NA SNELS DCGTM BERGMAN W
Citation
Mm. Hulshof et al., MULTIPLE AGMINATE SPITZ NEVI, Melanoma research, 8(2), 1998, pp. 156-160
Citations number
12
Categorie Soggetti
Oncology,"Dermatology & Venereal Diseases
Journal title
Melanoma research → ACNP
ISSN journal
09608931
Volume
8
Issue
2
Year of publication
1998
Pages
156 - 160
Database
ISI
SICI code
0960-8931(1998)8:2<156:>2.0.ZU;2-V
Abstract
We report two patients with multiple agminate Spitz naevi (MASM), a ra re disorder. In case 1, a 16-year-old girl, the results of chromosomal investigation of fibroblasts from the affected area (translocation 45 , X, t(4; 7) (p14; p22) in a mosaic pattern) suggest that early during embryogenesis a de novo reciprocal translocation has occurred between chromosomes 4 and 7. This resulted in the skin lesions as described o n the right shoulder, arm and hand. The melanoma risk in MASM is also discussed. (C) 1998 Lippincott-Raven Publishers.