VASCULAR TARGETED RADIOIMMUNOTHERAPY WITH BI-213 - AN ALPHA-PARTICLE EMITTER

To destroy both tumor blood vessels and adjacent tumor cells, an cu pa rticle emitter, Bi-213, has been targeted with a monoclonal antibody ( MAb) to vessels that feed lung tumors in mice. Animals, bearing approx imately 100 EMT-6 carcinomas each of 50-400 cells in size in the lung, that were treated with 120 mu Ci of Bi-213-MAb 201B were all cured of their disease, Animals treated when tumors were larger (10(3)-10(4) c ells) had extended life spans, but a small number of residual tumors e ventually killed the animals. Significant extension of life span was a lso induced with another tumor model - rat tracheal carcinoma growing in the lungs of SCID mice that were then treated with 136 mu Ci Bi-213 -MAb B-201. These studies indicate that attack of both blood vessels a nd tumor cells simultaneously is an effective mode of cancer treatment . (C) 1998 Elsevier Science Inc.