Sj. Kennel et S. Mirzadeh, VASCULAR TARGETED RADIOIMMUNOTHERAPY WITH BI-213 - AN ALPHA-PARTICLE EMITTER, Nuclear medicine and biology, 25(3), 1998, pp. 241-246
To destroy both tumor blood vessels and adjacent tumor cells, an cu pa
rticle emitter, Bi-213, has been targeted with a monoclonal antibody (
MAb) to vessels that feed lung tumors in mice. Animals, bearing approx
imately 100 EMT-6 carcinomas each of 50-400 cells in size in the lung,
that were treated with 120 mu Ci of Bi-213-MAb 201B were all cured of
their disease, Animals treated when tumors were larger (10(3)-10(4) c
ells) had extended life spans, but a small number of residual tumors e
ventually killed the animals. Significant extension of life span was a
lso induced with another tumor model - rat tracheal carcinoma growing
in the lungs of SCID mice that were then treated with 136 mu Ci Bi-213
-MAb B-201. These studies indicate that attack of both blood vessels a
nd tumor cells simultaneously is an effective mode of cancer treatment
. (C) 1998 Elsevier Science Inc.