IN-VIVO CARDIOTONIC ACTIVITY OF ARYL-SUBSTITUTED AND PYRIDYL-SUBSTITUTED FUSED IMIDAZOLES

Authors
ANDREANI A LEONI A MORIGI R BOSSA R CHIERICOZZI M GALATULAS I
Citation
A. Andreani et al., IN-VIVO CARDIOTONIC ACTIVITY OF ARYL-SUBSTITUTED AND PYRIDYL-SUBSTITUTED FUSED IMIDAZOLES, Arzneimittel-Forschung, 48(3), 1998, pp. 232-235
Citations number
11
Categorie Soggetti
Pharmacology & Pharmacy","Chemistry Medicinal
Journal title
Arzneimittel-Forschung → ACNP
ISSN journal
00044172
Volume
48
Issue
3
Year of publication
1998
Pages
232 - 235
Database
ISI
SICI code
0004-4172(1998)48:3<232:ICAOAA>2.0.ZU;2-3
Abstract
Two new imidazo[2,1-b]thiazoles related to sulmazole were synthesized and subjected to an in vivo cardiotonic assay with 14 analog compounds which gave the best results in previously reported in vitro tests. Th e data obtained show that three substituents (3-pyridyl, 4-pyridyl and 2,5-dimethoxyphenyl group) are useful pharmacophoric groups in modula ting the in vivo cardiotonic activity of the fused imidazoles consider ed.