RESULTANT BOND MOMENT AS A NEWLY DEVELOPED ELECTRONIC PARAMETER IN THE DESIGN OF ANTIBACTERIAL, ANTIPROTOZOAL NITROIMIDAZOLE DERIVATIVES

Nineteen nitroimidazole derivatives have been reported to be effective antibacterial against one strain each of Bacteroides fragilis and Clo stridium perfringens. The negative logarithms of minimum inhibitory co ncentrations (MICs) of these nitroimidazoles were fitted by a biostati stical relation involving a newly designed structural descriptor, the Resultant Bond Moment (RBM). RBM was developed on the basis of the che mical attribute of bend moments of heteroatoms. RBM reflects the elect ronic characteristic of the molecule. Apart from this, steric, electro nic, and hydrophobic parameters were also utilised in the search of a best fit regression equation. On the basis of these equations new inve stigative nitroimidazole derivatives have been predicted concerning th eir antibacterial and antiprotozoal efficacy.