ANTIBACTERIAL ACTIVITY OF RHODIUM, IRIDIUM, AND RUTHENIUM TRIPODAL PHOSPHINE COMPLEXES

Twenty-eight rhodium, iridium, or ruthenium complexes were evaluated f or their in vitro antibacterial activity against Enterococcus faecalis ATCC 29212, Staphylococcus aureus ATCC 29213, Escherichia coli ATCC 2 5922 and Pseudomonaa aeruginosa ATCC 27853. Ten compounds showed an an tibacterial activity against Enterococcus faecalis ATCC 29212 and Stap hylococcus aureus ATCC 29213 with a range of the minimum inhibitory co ncentrations (MICs) between 16 and 125 mu g/ml. None of the compounds exhibited antimicrobial activity against the gram-negative strains E. coli ATCC 25922 or Pseudomonas aeruginosa ATCC 29213 with a concentrat ion range between 4 and 500 mu g/ml.