GASTRIC-EMPTYING OF THE LIQUID, SOLID AND OIL PHASE OF A MEAL IN NORMAL VOLUNTEERS AND PATIENTS WITH BILLROTH-II GASTROJEJUNOSTOMY

Background The relationship between gastric emptying of different phas es of a meal in humans has only been partly studied in normal subjects and in patients with previous gastric surgery. Methods In the present study, gastric emptying of the liquid, solid and oil phase and the re lationship between the phases was evaluated in 10 normal control subje cts and in seven patients with Billroth II gastrojejunostomy using bre ath test technology. Results Gastric emptying in normal subjects showe d a clear separation between the emptying of the liquid, solid and oil phase. In healthy volunteers, the liquid phase emptied in the same ma nner in the presence of a solid phase as in the presence of an oil pha se. In contrast, the oil phase emptied more slowly with liquids than w ith solids. The emptying rate of the oil phase was not only inversely related to the amount administered but was also dependent on its chemi cal composition. Gastric emptying in patients with Billroth II gastroe nterostomy was characterized by a complete loss of discrimination betw een the different phases of the meal, with an extremely fast emptying of the oil phase compared with normal control subjects. Conclusion In normal subjects, the liquid, solid and oil phase of a meal are emptied differently. In patients with Billroth II gastrojejunostomy, dumping of the oil phase is the most pronounced difference from the normal phy siology of gastric emptying. This could be one of the reasons why Bill roth II gastrectomy may be associated with fat malabsorption.