ACTIVATION-INACTIVATION OF HIV-1 IN THE LUNG

The lung is prominently afflicted during the course of HIV-1 disease b y both infectious and noninfectious complications. Direct or indirect effects of HIV-1 are likely central to the pathogenesis of these compl ications. Thus, any changes in viral load locally would negatively imp act on the lung. This review focuses on the endogenous influences (imm une effector cells, surfactant) and the exogenous factors (including i nfections such as tuberculosis and noninfectious exposures like cigare tte smoke) that may contribute to activation or inactivation of HIV-1 in the lung.