BLOOD-GLUCOSE, GASTRIC-EMPTYING, AND ORO- COECAL TRANSIT-TIME AFTER ACONVENTIONAL BREAKFAST VS A KOLLATH BREAKFAST

Blood glucose kinetics and intestinal transit times were investigated in 12 adult volunteers aged 28 to 52 years after ingestion of a conven tional morning meal made up of white flour rolls, butter, marmelade, a nd coffee with sugar as compared with an isocaloric Kollath-breakfast consisting of whole wheat flakes as a basis. For estimation of gastric emptying time the sodium-[C-13]acetate breath test technique was used . Oro-coecal transit time and gastric emptying were determined by simu ltaneous administration of lactose[C-13]ureide and consecutive drawing s of breath samples in intervals of 15, 30, and 60 min through 12 h. T he (CO2)-C-13-excess of the breath test samples was measured by contin uous flow isotope ratio mass spectrometry. The postprandial rise in bl ood glucose following the ingestion of the Kollath-breakfast was lower as compared with the conventional morning meal, showing significant d ifferences between the 90 min values and the area below the blood gluc ose curve. The half time of gastric emptying was not different between the two breakfast versions (1.7 vs. 1.6 h). The oro-coecal transit ti me averaged out at 4.2 h after the Kollath-breakfast and 5.3 h followi ng the conventional morning meal. Likewise, there were no significant differences in the coecal retention time nor in the cumulative percent age of (CO2)-C-13-exhalation between the two breakfast versions. Conce rning the blood glucose kinetics the differences in the nutritional ph ysiology between the breakfast based on whole wheat flakes and the con ventional breakfast as claimed by Kollath were only detectable in outl ines in our study. Gastric emptying time showed no differences between the two breakfast versions.