ATYPICAL SPONTANEOUS FACTOR-VIII INHIBITOR - SPECIFIC DIAGNOSTICS ANDTHERAPY OF ACUTE BLEEDING

Differentiation of rapidly binding coagulation factor inhibitors from antiphospholipid antibodies is a challenge for the hemostaseologic lab oratory, especially with respect to the different therapeutic conseque nces. Several immunological and functional assays for the diagnosis of these disorders have been proposed. Here we report the clinical and l aboratory findings of a 65-year-old man who developed severe bleeding after a tooth extraction. The process leading to the diagnosis of a sp ontaneous atypical factor VIII inhibitor and the value of different la boratory tests are discussed.