LOCALIZATION OF ARYL SULFOTRANSFERASE EXPRESSION IN HUMAN TISSUES USING HYBRIDIZATION HISTOCHEMISTRY AND IMMUNOHISTOCHEMISTRY

Authors
WINDMILL KF CHRISTIANSEN A TEUSNER JT BHASKER CR BIRKETT DJ ZHU XY MCMANUS ME
Citation
Kf. Windmill et al., LOCALIZATION OF ARYL SULFOTRANSFERASE EXPRESSION IN HUMAN TISSUES USING HYBRIDIZATION HISTOCHEMISTRY AND IMMUNOHISTOCHEMISTRY, Chemico-biological interactions, 109(1-3), 1998, pp. 341-346
Citations number
18
Categorie Soggetti
Pharmacology & Pharmacy","Chemistry Medicinal
Journal title
Chemico-biological interactions → ACNP
ISSN journal
00092797
Volume
109
Issue
1-3
Year of publication
1998
Pages
341 - 346
Database
ISI
SICI code
0009-2797(1998)109:1-3<341:LOASEI>2.0.ZU;2-9
Abstract
To date, the laboratory has cloned seven unique human sulfotransferase s; five aryl sulfotransferases (HAST1, HAST2, HAST3, HAST4 and HAST4v) , an estrogen sulfotransferase and a dehydroepiandrosterone sulfotrans ferase. The cellular distribution of human aryl sulfotransferases in h uman hepatic and extrahepatic tissues has been determined using the te chniques of hybridization histochemistry and immunohistochemistry. Hum an aryl sulfotransferase expression was detected in liver, epithelial cells of the gastrointestinal mucosal layer, epithelial cells lining b ronchioles and in mammary duct epithelial cells. (C) 1998 Elsevier Sci ence Ireland Ltd. All rights reserved.