SYNTHETIC ANALOGS OF NETROPSIN AND DISTAMYCIN - SYNTHESIS OF A NEW PYRIDINE AND CARBOCYCLIC ANALOGS OF THE PYRROLECARBOXAMIDE ANTITUMOR ANTIBIOTICS

A new series of pyridine-containing analogues III-XXII of distamycin A and netropsin was investigated by the molecular mechanics technique a nd molecular modelling. A pyridine analogue of netropsin (VII) is desc ribed, the first compound based on molecular studies, and two carbocyc lic analogues of distamycin A with an N-terminal chloro-or bromoacetyl group (VIa, VIIa) were synthesized, as well as carbocyclic analogues of netropsin (VIIIb, Xb), potential carriers of alkylating elements. T he potential use of VIa, VII, VIIa, VIIIb and Xb as carriers to place into the minor groove of DNA chemical groups capable of modifying DNA, is discussed.