HIGH-MOLECULAR-MASS DEXTRAN SULFATE INCREASES EXPRESSION OF HIV-1 CORECEPTOR CCR-5 IN MACROPHAGE-MONOCYTES IN CULTURE

Authors
JAGODZINSKI PP TRZECIAK WH
Citation
Pp. Jagodzinski et Wh. Trzeciak, HIGH-MOLECULAR-MASS DEXTRAN SULFATE INCREASES EXPRESSION OF HIV-1 CORECEPTOR CCR-5 IN MACROPHAGE-MONOCYTES IN CULTURE, Acta Biochimica Polonica, 45(1), 1998, pp. 241-244
Citations number
11
Categorie Soggetti
Biology
Journal title
Acta Biochimica Polonica → ACNP
ISSN journal
0001527X
Volume
45
Issue
1
Year of publication
1998
Pages
241 - 244
Database
ISI
SICI code
0001-527X(1998)45:1<241:HDSIEO>2.0.ZU;2-6
Abstract
It has been reported that high molecular mass dextran sulfate (HMDS) e nhances the infection of monocyte-macrophages by HIV-1. We observed th at in monocyte-macrophages maintained in the presence of HMDS the expr ession of HIV-1 coreceptor CCR-5 was increased approximately 5-fold at the transcriptional level. We postulate that the increased expression of CCR-5 might be responsible for HMDS-enhanced infectivity of monocy te-macrophages by HIV-1.