GASTRIN PROCESSING - FROM BIOCHEMICAL OBSCURITY TO UNIQUE PHYSIOLOGICAL ACTIONS

Authors
DICKINSON CJ SEVA C YAMADA T
Citation
Cj. Dickinson et al., GASTRIN PROCESSING - FROM BIOCHEMICAL OBSCURITY TO UNIQUE PHYSIOLOGICAL ACTIONS, News in physiological sciences, 12, 1997, pp. 9-15
Citations number
15
Journal title
News in physiological sciences → ACNP
ISSN journal
08861714
Volume
12
Year of publication
1997
Pages
9 - 15
Database
ISI
SICI code
0886-1714(1997)12:<9:GP-FBO>2.0.ZU;2-8
Abstract
Posttranslational processing is essential for the biological activatio n of many peptide hormones, Only fully processed and amidated gastrin, a peptide secreted by the stomach, stimulates acid secretion. However , both amidated gastrin and ifs glycine-extended precursor stimulate c ellular proliferation through selective receptors, suggesting that pos ttranslational processing is critical to gastrointestinal physiology.