LIFE-THREATENING CARBOPLATIN HYPERSENSITIVITY DURING CONDITIONING FORAUTOLOGOUS PBSC TRANSPLANTATION - SUCCESSFUL RECHALLENGE AFTER DESENSITIZATION

Carboplatin hypersensitivity has rarely been reported in patients rece iving repeated cycles of therapy, but has not been reported in transpl ant settings, We report a case of carboplatin hypersensitivity during conditioning for autologous PBSC transplantation. The patient suddenly developed chest tightness, hemoptysis, hypoxia and hypotension, resul ting in a transient myocardial ischemia, The pathophysiologic mechanis m for the event seemed to be non-immune-mediated direct histamine rele ase given the lack of prior exposure to platinum. Contrary to advice n ot to continue further treatment with carboplatin by some authors, we successfully desensitized the patient and subsequently gave more carbo platin as a part of conditioning. Awareness of carboplatin as one of t he causes of hypersensitivity may help avoid further problems either b y substitution or desensitization, along with premedications.