CALCIUM DOBESILATE INCREASES ENDOTHELIUM-DEPENDENT RELAXATION IN ISOLATED RABBIT AORTA

1. The aim of this study was to investigate the effects of calcium dob esilate on relaxant and contractile responses in the isolated rabbit a orta. 2. Calcium dobesilate (10(-6) and 10(-4) M) shifted the concentr ation-response curve induced by noradrenaline (10(-8)-10(-4) M) downwa rd and to the right, the IC50 being 5.1+/-1.1x10(-7) M in the control and 7.5+/-1.2x10(-6) M and 3.1+/-1.9x10(-6) M in the presence of calci um dobesilate, 10(-6) M and 10(-4) M respectively. 3. Calcium dobesila te, 10(-5) M, increased the endothelium-dependent relaxation induced b y acetylcholine (10(-8)-10(-5) M) but had no actions in the absence of endothelium. (C) 1998 Elsevier Science Inc.