THE EFFECTS OF BONE-RESORPTION INHIBITORS ON THE GROWTH-PLATE AND PROXIMAL TIBIAL METAPHYSIS OF RATS - CLINICAL IMPLICATIONS

This study investigated the effects of diphosphonates at scalar doses in a high bone turnover structure, namely, the proximal tibial metaphy sis of rats. Arrest of bone modeling was represented by cylindrical-sh aped metaphyses, increased height of the perichondrial bone bark, and persistence of primary metaphyseal trabeculae; these changes were dose -related. Higher doses of the inhibitors produced extension of the gro wth plate and arrest of the mineralization process. The dose-related d issociation between the effects on bone resorption and mineralization allows the therapeutic use of this class of drugs.