SYNTHESIS AND STEREOCHEMISTRY OF AXINASTATIN-4

Authors
BATES RB CALDERA S RUANE MD
Citation
Rb. Bates et al., SYNTHESIS AND STEREOCHEMISTRY OF AXINASTATIN-4, Journal of natural products, 61(3), 1998, pp. 405-405
Citations number
9
Categorie Soggetti
Chemistry Medicinal","Plant Sciences","Pharmacology & Pharmacy
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
61
Issue
3
Year of publication
1998
Pages
405 - 405
Database
ISI
SICI code
0163-3864(1998)61:3<405:SASOA>2.0.ZU;2-3
Abstract
Axinastatin 4 from a marine sponge was synthesized by high-dilution BO P-Cl cyclization of Trp-Val-Pro-Leu-Thr-Pro-Leu in 94% yield (only 2.5 % at normal dilution), showing the configurations of the last three am ino acids to be S. Synthetic axinastatin 4 was devoid of cytostatic ac tivity.