DIFFERENCES IN PLASMA-CONCENTRATIONS OF THE D-THREO AND L-THREO METHYLPHENIDATE ENANTIOMERS IN RESPONDING AND NON-RESPONDING CHILDREN WITH ATTENTION-DEFICIT HYPERACTIVITY DISORDER

Authors
JONKMAN LM VERBATEN MN DEBOER D MAES RAA BUITELAAR JK KEMNER C VANENGELAND H KOELEGA HS
Citation
Lm. Jonkman et al., DIFFERENCES IN PLASMA-CONCENTRATIONS OF THE D-THREO AND L-THREO METHYLPHENIDATE ENANTIOMERS IN RESPONDING AND NON-RESPONDING CHILDREN WITH ATTENTION-DEFICIT HYPERACTIVITY DISORDER, Psychiatry research, 78(1-2), 1998, pp. 115-118
Citations number
6
Categorie Soggetti
Psychiatry,Psychiatry
Journal title
Psychiatry research → ACNP
ISSN journal
01651781
Volume
78
Issue
1-2
Year of publication
1998
Pages
115 - 118
Database
ISI
SICI code
0165-1781(1998)78:1-2<115:DIPOTD>2.0.ZU;2-8
Abstract
Children with attention-deficit hyperactivity disorder who are categor ized as responders or non-responders to methylphenidate (MPH) on the b asis of their electrophysiological P3 response in a selective attentio n task differ in metabolic patterns of the D-and L-threo MPH enantiome rs. Non-responders showed significantly higher plasma concentrations o f both D-and L-threo MPH enantiomers. (C) 1998 Elsevier Science Irelan d Ltd.