Mucinous syringometaplasia is a rare condition characterized by the pr
esence of mucinous cells lining eccrine ducts. Because most occurrence
s are on the palms and soles, the disorder is generally considered to
be the result of chronic trauma or pressure. We describe an example of
mucinous metaplasia involving an apocrine duct on the left arm of a 5
7-year-old woman. Histopathologic study demonstrated that in deeper ar
eas of the invagination, the lining of the lumen consisted of columnar
cells showing decapitation secretion and that the invagination was co
nnected to a rudimentary hair follicle. These histopathologic features
support the possibility that the involved duct was an apocrine one. W
e discuss the differential diagnosis with those cutaneous adnexal neop
lasms in which the presence of mucinous cells has been described.