PATHOPHYSIOLOGY OF UPPER AIRWAY-OBSTRUCTION DURING SLEEP

Obstructive sleep apnea is a common medical disorder with significant adverse health consequences. The pathogenesis of pharyngeal obstructio n during sleep, however, remains elusive. This article addresses the k ey mechanisms of upper airway (UA) obstruction including the role of t ransmural pressure, pharyngeal compliance, pharyngeal dilating muscle activity and non-neuromuscular factors. A proposed scheme of the patho physiology of UA obstruction is outlined.