ALL WRAPPED UP

Authors
CHOO Y SCHWABE JWR
Citation
Y. Choo et Jwr. Schwabe, ALL WRAPPED UP, Nature structural biology, 5(4), 1998, pp. 253-255
Citations number
19
Categorie Soggetti
Biophysics,Biology
Journal title
Nature structural biology → ACNP
ISSN journal
10728368
Volume
5
Issue
4
Year of publication
1998
Pages
253 - 255
Database
ISI
SICI code
1072-8368(1998)5:4<253:>2.0.ZU;2-T
Abstract
How is it possible that nine small repeated 'zinc finger' units (each spanning just 3 or 4 base pairs) can protect the whole 50 base pair bi nding site of TFIIIA and why should such a periodic protein structure give rise to such an asymmetric footprint on DNA? The crystal structur e of the first six fingers of TFIIIA bound to 31 base pairs of DNA exp lains everything: not all zinc fingers act alike.