H. Yokoyama et al., URINARY LEVELS OF CHEMOKINES (MCAF MCP-1, IL-8) REFLECT DISTINCT DISEASE ACTIVITIES AND PHASES OF HUMAN-IGA NEPHROPATHY/, Journal of leukocyte biology, 63(4), 1998, pp. 493-499
Leukocytes have been implicated to be involved in the pathogenesis of
IgA nephropathy (IgAN). To clarify the precise molecular mechanism of
recruitment and activation of leukocytes in the subgroups of IgAN, lat
ent, acute, and chronic types, we studied monocyte chemotactic and act
ivating factor (MCAF/MCP-1) and interleukin (IL)-8 in urines and renal
expression of these cytokines, Urinary MCAF levels were significantly
higher in chronic type, and were correlated with pathological progres
sive factors such as mesangial proliferation and interstitial cellular
infiltration associated with CD68-positive macrophage, On the other h
and, urinary IL-8 elevated only in acute type and were correlated with
glomerular endocapillary proliferation and the degree of hematuria, I
n immunohistochemical study, IL-8 was mainly observed in glomeruli, ot
herwise MCAF in vascular endothelial cells, tubular epithelial cells,
and infiltrated mononuclear cells in the interstitial lesions, These o
bservations demonstrated that MCAF and IL-8 were differentially expres
sed in kidneys with IgAN, and their subtypes, and suggest that chemoki
nes may be involved in the pathogenesis of IgAN at distinct phases or
pathological lesions, possibly through the recruitment and activation
of a distinct type of leukocyte.