EFFECTIVE MULTIPLE-SOLVENT SUPPRESSION SCHEME USING THE EXCITATION SCULPTING PRINCIPLE

An interesting and simple approach to effective multiple-solvent suppr ession is proposed using the basic principles of the excitation sculpt ing methodology. Flat baseline and ultra-clean NMR spectra are usually obtained under standard conditions using a modified double pulsed fie ld gradient echo scheme in samples containing mixtures of non-deuterat ed solvents. The simple performance of such an approach, the high tole rance to experimental mis-settings, the impressive level of solvent su ppression and the easy incorporation of the proposed scheme in multi-d imensional NMR experiments make this method suitable for possible appl ications in liquid chromatography NMR. (C) 1998 John Wiley & Sons, Ltd .