NON SEGMENTED CONTINUOUS-FLOW SYSTEM WITH POLAROGRAPHIC DETECTION FORTHE DETERMINATION OF RANITIDINE IN PHARMACEUTICAL FORMULATIONS AND URINE

In this work we developed a method by flow injection analysis for the determination of ranitidine in pharmaceutical forms and urine, using a polarographic flow through cell as detection system which has been de signed recently in our laboratory. The method is based on the reductio n of the group nitro of the drug to the hydroxylamine derivative by ap plying a potential of -1.40 V vs mercury pool electrode. It was found a determination range of 2.38x10(-5) -1.0x10(-3) M ranitidine, with a detection limit of 7.15x10(-6) M. The relative standard deviation (n = 11) for a concentration level of 1.0x10(-4) M was 2.1%, which is comp arable with the obtained by the manual methodology. The accuracy of th e method was evaluated by comparison of the results with those obtaine d by d.c. polarography and UV spectrophotometry and the results were q uite comparable.