SYNTHESIS OF (-ETHOSUXIMIDES AND (-)-ETHOSUXIMIDES UTILIZING ASYMMETRIC NITROOLEFINATION())

Authors
NISHIDE K KATOH T IMAZATO H NODE M
Citation
K. Nishide et al., SYNTHESIS OF (-ETHOSUXIMIDES AND (-)-ETHOSUXIMIDES UTILIZING ASYMMETRIC NITROOLEFINATION()), Heterocycles, 47(2), 1998, pp. 839-845
Citations number
29
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
47
Issue
2
Year of publication
1998
Pages
839 - 845
Database
ISI
SICI code
0385-5414(1998)47:2<839:SO(A(U>2.0.ZU;2-E
Abstract
Both enantiomers of ethosuximide were synthesized from (GS)-(-)- and ( R)-(+)-2-methyl-2-[(E)-2-nitroethenyl]-(1), which were obtained by asy mmetric nitroolefination of alpha-methyl-gamma-butyrolactone, via the lactone carboxylic acid (3).