I. Ugi et al., MCR-6 - CHIRAL 2,6-PIPERAZINEDIONES VIA UGI REACTIONS WITH ALPHA-AMINO-ACIDS, CARBONYL-COMPOUNDS, ISOCYANIDES AND ALCOHOLS, Heterocycles, 47(2), 1998, pp. 965-975
A simple one-pot reaction based on the well known Ugi reaction for the
generation of 2,6-piperazindiones is described, involving the multico
mponent reaction of alpha-amino acids, carbonylcompounds, isocyanides
and alcohols.