DIASTEREOMERIC ROXY-2-PHENYLETHYL)-1,4,7,10-TETRAAZACYCLODODECANE ANDITS ALKALI-METAL COMPLEX-IONS - A POTENTIOMETRIC TITRATION, NUCLEAR-MAGNETIC-RESONANCE, AND MOLECULAR-ORBITAL STUDY
Sl. Whitbread et al., DIASTEREOMERIC ROXY-2-PHENYLETHYL)-1,4,7,10-TETRAAZACYCLODODECANE ANDITS ALKALI-METAL COMPLEX-IONS - A POTENTIOMETRIC TITRATION, NUCLEAR-MAGNETIC-RESONANCE, AND MOLECULAR-ORBITAL STUDY, Journal of the American Chemical Society, 120(12), 1998, pp. 2862-2869
C-13 NMR studies are consistent with roxy-2-phenylethyl)-1,4,7,10-tetr
aazacyclododecane (Delta R-thpec12) and its eight-coordinate alkali-me
tal complexes, Delta[M(R-thpec12)](+), existing predominantly as singl
e square antiprismatic Delta diastereomers in dimethylformamide. Molec
ular orbital calculations show the parallel square oxygen and nitrogen
planes to delineate the square antiprismatic structure of Delta R-thp
ec12 and Delta[M(R-thpec12)](+) where the basket defined by the four p
henyl groups of Delta R-thpec12 becomes increasingly shallow as the M radius increases from Na+ to Cs+ and the four oxygens move further ap
art. An intramolecular exchange process, involving double inversion of
all four nitrogen centers, occurs in Delta R-thpec12 for which k(298.
2 K) = 46300 +/- 1800 s(-1), Delta H double dagger = 40.8 +/- 0.4 kJ m
ol(-1), and Delta S double dagger = -18.8 +/- 1.7 J K-1 mol(-1). In [M
(R-thpec12)](+) this process is characterized by k(298.2 K) = 233 +/-
2, 98 +/- 1, 4900 +/- 100, 33500 +/- 1000, and 34500 +/- 1100 s(-1), D
elta H double dagger = 34.6 +/- 0.3, 46.1 +/- 0.2, 42.7 +/- 0.3, 39.1
+/- 0.3, and 38.5 +/- 0.3 kJ mol(-1), and Delta S double dagger = -83.
5 +/- 1.1, -52.2 +/- 0.7, -31.1 +/- 1.2, -27.2 +/- 1.2, and -28.9 +/-
1.3 J K-1 mol(-1), respectively, when M+ = Li+, Na+, K+, Rb+, and Cs+.
For intermolecular ligand exchange on Delta[M(R-thpec12)](+), decompl
exation is characterized by k(d)(298.2 K) = 396 +/- 3, 156 +/- 3, and
152000 +/- 6000 s(-1), Delta H-d double dagger = 46.0 +/- 0.3, 62.3 +/
- 0.5, and 69.8 +/- 0.5 kJ mol(-1), and Delta S-d double dagger = -40.
9 +/- 1.0, 6.0 +/- 1.9, and 88.4 +/- 2.1 J K-1 mol(-1), respectively,
when M+ = Li+, Na+, and K+. The stability constant, K, of Delta[M(R-th
pec12)](+) varies as M+ changes in the sequence Li+ (3.13 +/- 0.05), N
a+ (4.25 +/- 0.05), K+ (4.10 +/- 0.05), Rb+ (3.57 +/- 0.05), Cs+ (3.47
+/- 0.05), and Ag+ (8.14 +/- 0.03), where the figures in parentheses
are log(K/(dm(3) mol(-1))) determined in dimethylformamide by potentio
metric titration at 298.2 K and I = 0.05 mol dm(-3) (NEt4ClO4).