AUTOMATED SYNTHESIS OF 6-[F-18]FLUORO-L-DOPA USING MODIFIED POLYSTYRENE SUPPORTS WITH BOUND 6-MERCURIC DOPA PRECURSORS

Authors
SZAJEK LP CHANNING MA ECKELMAN WC
Citation
Lp. Szajek et al., AUTOMATED SYNTHESIS OF 6-[F-18]FLUORO-L-DOPA USING MODIFIED POLYSTYRENE SUPPORTS WITH BOUND 6-MERCURIC DOPA PRECURSORS, Applied radiation and isotopes, 49(7), 1998, pp. 795-804
Citations number
9
Categorie Soggetti
Nuclear Sciences & Tecnology","Radiology,Nuclear Medicine & Medical Imaging","Chemistry Inorganic & Nuclear
Journal title
Applied radiation and isotopes
ISSN journal
09698043 → ACNP
Volume
49
Issue
7
Year of publication
1998
Pages
795 - 804
Database
ISI
SICI code
0969-8043(1998)49:7<795:ASO6UM>2.0.ZU;2-D
Abstract
Polystyrene polymer substrates were prepared having protected L-DOPA p recursors mercurated in the 6-position. When treated with gaseous [F-1 8]acetyl hypofluorite followed by HI hydrolysis, 6-[F-18]fluoro-3,4-di hydroxy-L-phenylalanine (6-[F-18]fluoro-L-DOPA) was obtained in 2-23% overall chemical yield. The highest yield was obtained using P-CH2CO2H g(pro-DOPA), where P = polystyrene and pro-DOPA is protected L-DOPA. T hese modified polystyrene supports are easily prepared, require no spe cial storage treatment, and are convenient to use in an automated 6-[F -18]fluoro-L-DOPA production system. Published by Elsevier Science Ltd .