K. Katsuno et al., THE ADVERSE EFFECT OF COMMERCIAL DENTIN-BONDING SYSTEMS ON THE SKIN OF GUINEA-PIGS, Journal of oral rehabilitation, 25(3), 1998, pp. 180-184
It was widely known that 2-hydroxyethyl methacrylate (2-HEMA) can caus
e contact dermatitis. Commercially available dentine primers and denti
ne bonding agents that contain 2-HEMA are widely used. The purpose of
this study was to investigate the cumulative irritation and delayed hy
persensitivity caused by commercial dentine bonding systems when appli
ed to the skin of guinea pigs. We have concluded that almost no dentin
e bonding systems cause cumulative irritation, but some commercially a
vailable dentine bonding systems may produce delayed hypersensitivity.