EFFECTS OF A URINARY FACTOR FROM WOMEN IN EARLY-PREGNANCY ON HIV-1, SIV AND ASSOCIATED DISEASE

The effects of clinical grade crude preparations of human chorionic go nadotropin (hCG) on Kaposi's sarcoma, HIV, SIV and hematopoiesis were examined in vitro and in vivo. In contrast to previous studies, we rep ort that the antiviral activity of hCG associated factors is not due t o the native hCG heterodimer, including its purified subunits or its m ajor degradation product, the beta-core. Using gel permeation chromato graphy of the clinical grade hCC and urine concentrates from pregnant women, we demonstrate that an as yet unidentified hCC associated facto r (HAF) with anti-HIV, anti-SIV, anti-KS and pro-hematopoietic activit ies elutes as two peaks corresponding to 15-30 kDa and 2-4 kDa.